人胎儿脑中甲胎蛋白的个体发生

Ontogeny of alpha-foetoprotein in human foetal brain.

作者信息

Ali M, Balapure A K, Singh D R, Shukla R N, Sahib M K

出版信息

Brain Res. 1981 Mar 2;207(2):459-64. doi: 10.1016/0006-8993(81)90379-6.

Abstract

Alpha-foetoprotein (AFP) was found to be present in human foetal brain during early embryonic life. Antigenically and electrophoretically foetal brain AFP is similar to that found in human foetal serum. Like serum AFP it did not bind oestradiol. Developmental profile of the proteins in foetal brain was distinct from that observed in foetal serum, amniotic fluid and maternal serum compartments. Peak levels of brain AFP were obtained in foetuses in the 20th week of gestation. These levels decreased rapidly and no AFP could be detected in foetal brains derived from the third trimester of pregnancy. The origin of AFP and its possible role in foetal brain development is discussed.

摘要

在胚胎早期生命阶段，人们发现甲胎蛋白（AFP）存在于人类胎儿大脑中。从抗原性和电泳方面来看，胎儿大脑中的AFP与人类胎儿血清中的AFP相似。与血清AFP一样，它不与雌二醇结合。胎儿大脑中蛋白质的发育情况与胎儿血清、羊水和母体血清中的情况不同。妊娠第20周的胎儿大脑中AFP水平达到峰值。这些水平迅速下降，在妊娠晚期的胎儿大脑中检测不到AFP。文中讨论了AFP的来源及其在胎儿大脑发育中的可能作用。