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人、小鼠和大鼠皮肤表面脂质组分对曼氏血吸虫尾蚴“体外”穿透的重要性(作者译)

[The importance of man, mouse and rat skin surface lipid fractions on the "in vitro" penetration of "Schistosoma mansoni" cercariae (author's transl)].

作者信息

Cicchini T, Passi S, Simoni L, Messeri E, Belli M

出版信息

Ann Sclavo. 1977 Sep-Oct;19(5):1033-42.

PMID:616258
Abstract

The AA. have studied in this research, the rôle explicated in vitro from the lipids contained in a man's skin, in a rat of the Wistar experimental group and in a mouse of the Swiss one. They have seen that some lipids fractions, as triglycerides, waxes and squalenes explicate an action that favours the penetration of the cercariae in vitro on a plate of agar and that such an action is due to the unsaturation in the above said fractions of sebaceous origin. On the contrary the lipids of skin origin as sterols and their esters inhibit the penetration.

摘要

研究人员在本研究中对取自一名男性皮肤、Wistar实验组大鼠和瑞士小鼠的脂质在体外发挥的作用进行了研究。他们发现,一些脂质组分,如甘油三酯、蜡和角鲨烯,在体外对琼脂平板上的尾蚴穿透具有促进作用,且这种作用归因于上述皮脂腺来源组分中的不饱和键。相反,皮肤来源的脂质,如甾醇及其酯类,则会抑制尾蚴的穿透。

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