Sidenius P, Jakobsen J
Diabetologia. 1981 Feb;20(2):110-2. doi: 10.1007/BF00262011.
The accumulation of 3H-fucose labelled glycoprotein and 35S-methionine labelled protein carried by the retrograde axonal transport in the sensory fibres of the sciatic nerve was examined on the day after injection of streptozotocin in rats. The accumulation of fucose-label was reduced (2.8 +/- 0.4 (SD) versus 2.1 +/- 0.5 (arbitrary units), 2p = 0.0044) indicating a decreased retrograde flux of glycoproteins. This early transport abnormality could have a key role in the development of peripheral neuropathy in diabetes.
在给大鼠注射链脲佐菌素后的第二天，检测了坐骨神经感觉纤维中通过逆行轴突运输携带的3H-岩藻糖标记糖蛋白和35S-甲硫氨酸标记蛋白的积累情况。岩藻糖标记物的积累减少（2.8±0.4（标准差）对2.1±0.5（任意单位），P=0.0044），表明糖蛋白的逆行运输通量降低。这种早期运输异常可能在糖尿病周围神经病变的发展中起关键作用。
