Drawert J, Stein P
Folia Haematol Int Mag Klin Morphol Blutforsch. 1980;107(6):914-8.
Polyamino-polycarboxyl acids (ampholines) used for electrofocusing have the effect of shortening the coagulation time during the one stage test, which is in direct proportion to the activity of factor VIII already present. Compared with factor VIII, ampholine 5-7 and 7-10 have a different range of effect as far as their stimulating activity is concerned. For increasing their activity a minimum PPCS concentration of 0.1 m Mol/l is required in the test run. There is no own effect of these substances similar to factor VIII. The activity of factor IX and X is not influenced. Ampholines gained from acrylic acid and ethylenediamine will not enhance the activity of factor VIII in the course of the one stage test.
用于等电聚焦的聚氨基聚羧酸（两性电解质）在一期试验中具有缩短凝血时间的作用，且与已存在的凝血因子VIII活性成正比。就其刺激活性而言，与凝血因子VIII相比，两性电解质5-7和7-10具有不同的作用范围。在试验过程中，为提高其活性，需要至少0.1毫摩尔/升的PPCS浓度。这些物质本身没有类似凝血因子VIII的作用。凝血因子IX和X的活性不受影响。由丙烯酸和乙二胺制得的两性电解质在一期试验过程中不会增强凝血因子VIII的活性。
