Liebe S
Folia Haematol Int Mag Klin Morphol Blutforsch. 1975;102(4):454-61.
Polyaminopolycarboxyl acids (Ampholine, LKB producers Sweden) caused the antihaemophilic globulin (factor VIII) to be activated. This increase of activity revealed a linear dependence on Ampholine concentrations. Only those Ampholine molecules of alkaline pH areas positively charged under test conditions turned out to be efficient. The positive charge, therefore, seems to be significant for an activation. The coagulation activities were measured by determining the partial thromboplastin time (PTT) and the factor VIII in an one-phase test.
聚氨基聚羧酸（两性电解质，瑞典LKB公司生产）可使抗血友病球蛋白（因子VIII）激活。活性的这种增加显示出与两性电解质浓度呈线性相关。结果表明，只有在测试条件下带正电荷的碱性pH区域的那些两性电解质分子才有效。因此，正电荷似乎对激活具有重要意义。通过在单相试验中测定部分凝血活酶时间（PTT）和因子VIII来测量凝血活性。
