小鼠β2-微球蛋白与H-3和Ly-4连锁的证据。
Evidence for linkage of murine beta 2-microglobulin to H-3 and Ly-4.
作者信息
Goding J W
出版信息
J Immunol. 1981 Apr;126(4):1644-6.
Murine beta 2-microglobulin exists in 2 electrophoretically distinct forms; C57BL/6 mice possess the basic allele whereas BALB/c, CBA, AKR, and NZB possess the acidic allele. Mice heterozygous for beta 2-microglobulin express both alleles. Analysis of recombinant inbred mice suggests linkage of beta 2-microglobulin to H-2 or H-3. B10.C (28NX) mice (which possess the H-3c allele of BALB/c on a C57BL/10 background) possess the acid allele. Taken together, these results are consistent with the beta 2-microglobulin gene lying on chromosome 2, and being linked to H-3 and Ly-4.
小鼠β2-微球蛋白以两种电泳性质不同的形式存在；C57BL/6小鼠拥有碱性等位基因，而BALB/c、CBA、AKR和NZB拥有酸性等位基因。β2-微球蛋白杂合的小鼠表达两种等位基因。对重组近交系小鼠的分析表明β2-微球蛋白与H-2或H-3连锁。B10.C(28NX)小鼠（在C57BL/10背景上拥有BALB/c的H-3c等位基因）拥有酸性等位基因。综合来看，这些结果与β2-微球蛋白基因位于2号染色体上并与H-3和Ly-4连锁是一致的。
Zotero 插件