Hagino Y, Uematsu T, Tachibana M, Tsuru H
Jpn J Pharmacol. 1980 Aug;30(4):521-8. doi: 10.1254/jjp.30.521.
The effect of thyroid hormone on the activity of low Km cyclic AMP) phosphodiesterase of the particulate fraction from the kidney was investigated. This enzyme activity increased in the cortex from hypothyroid rats and reverted to the normal level after the subcutaneous administration of L-3,5,3'-triiodothyronine (T3) daily for 3 days. However, this hormone did not affect the enzymes from the normal rats. In vitro experiments revealed that T3 as well as various known phosphodiesterase inhibitors similarly inhibited the activity of low Km cyclic AMP phosphodiesterase from both normal and hypothyroid rat kidneys. The results of the present study suggest that the effect of thyroid hormone on cyclic AMP phosphodiesterase was not direct but was mediated by a modulation of the rate of protein synthesis and an unknown mechanism in the kidney.
研究了甲状腺激素对肾脏微粒体部分低 Km 环磷酸腺苷（cAMP）磷酸二酯酶活性的影响。甲状腺功能减退大鼠皮质中的这种酶活性增加，在每日皮下注射 L-3,5,3'-三碘甲状腺原氨酸（T3）3 天后恢复到正常水平。然而，这种激素对正常大鼠的酶没有影响。体外实验表明，T3 以及各种已知的磷酸二酯酶抑制剂同样抑制正常和甲状腺功能减退大鼠肾脏中低 Km 环磷酸腺苷磷酸二酯酶的活性。本研究结果表明，甲状腺激素对环磷酸腺苷磷酸二酯酶的作用不是直接的，而是通过调节肾脏中蛋白质合成速率和一种未知机制介导的。
