Gallacher D V, Petersen O H
Pflugers Arch. 1981 Jan;389(2):127-30. doi: 10.1007/BF00582102.
Direct effects of exogenously applied substance P on salivary acinar cells have been previously reported. This electro-physiological study confirms these direct effects in rat but not mouse parotid gland. We demonstrate that in the absence of autonomic blockade the peptide evokes marked responses which are blocked by atropine (10(-6) M). These effects cannot be attributed to direct activation of acinar cells and are presumably due to release of acetylcholine from parasympathetic nerve endings. We consider that substance P, in addition to direct effects, could act to modulate neuronal activity in salivary glands; a role already assigned to the peptide in the central nervous system.
先前已有报道外源性应用P物质对唾液腺泡细胞的直接作用。这项电生理研究证实了在大鼠而非小鼠腮腺中存在这些直接作用。我们证明，在没有自主神经阻滞的情况下，该肽引发的明显反应可被阿托品（10⁻⁶ M）阻断。这些作用不能归因于腺泡细胞的直接激活，推测是由于副交感神经末梢释放乙酰胆碱所致。我们认为，P物质除了具有直接作用外，还可能对唾液腺中的神经元活动起调节作用；该肽在中枢神经系统中已被赋予这一作用。
