Robinson S E, Schwartz J P, Costa E
Brain Res. 1980 Jan 20;182(1):11-7. doi: 10.1016/0006-8993(80)90826-4.
Substance P has been detected in the superior cervical ganglion and submaxillary gland of the rat by radioimmunoassay. Decentralization, section of the carotid sinus nerve, or deefferentation does not affect the level of substance P in the rat superior cervical ganglion. Superior cervical ganglionectomy does not affect the amount of substance P in the submaxillary gland; however, section of the chorda tympani or duct ligation significantly reduces substance P in the submaxillary gland. It is concluded that substance P in the superior cervical ganglion is not located in the preganglionic sympathetic neurons, afferents from the glossopharyngeal nerve or post-ganglionic neurons projecting to the submaxillary gland or carotid body. Substance P does not appear to be associated with sympathetic innervation of the submaxillary gland, but it is anatomically and functionally related to the chorda tympani and possibly involved in the parasympathetic innervation of the gland. Substance P may also be present in gland cells of the submaxillary gland.
通过放射免疫测定法已在大鼠的颈上神经节和颌下腺中检测到P物质。去神经支配、切断颈动脉窦神经或传出神经切断术均不影响大鼠颈上神经节中P物质的水平。颈上神经节切除术不影响颌下腺中P物质的含量；然而，切断鼓索或结扎导管会显著降低颌下腺中的P物质。得出的结论是，颈上神经节中的P物质不在节前交感神经元、来自舌咽神经的传入神经或投射至颌下腺或颈动脉体的节后神经元中。P物质似乎与颌下腺的交感神经支配无关，但在解剖学和功能上与鼓索有关，并且可能参与该腺体的副交感神经支配。P物质也可能存在于颌下腺的腺细胞中。
