5-羟基多巴，黑素生成的拉珀-梅森机制中的一种新化合物。
5-hydroxydopa, a new compound in the Raper-Mason scheme of melanogenesis.
作者信息
Hansson C, Rorsman H, Rosengren E
出版信息
Acta Derm Venereol. 1980;60(4):281-6.
PMID:6163271
Abstract
Oxidation of tyrosine or dopa by tyrosinase leads to the formation of 5-OH-dopa, a compound previously unknown in melanogenesis. 5-OH-dopa, first detected as an unknown compound on HPLC of the dopa-tyrosinase incubate, was purified by Al2O3-adsorption, semipreparative HPLC, and ion-exchange chromatography. 5-OH-dopa was identified by comparison with the authentic compound in several chromatographic systems, by electrochemical oxidation studies and by mass spectrometry.
摘要
酪氨酸酶将酪氨酸或多巴氧化会导致生成5-羟基多巴，这是一种在黑色素生成过程中此前未知的化合物。5-羟基多巴最初是在对多巴-酪氨酸酶孵育物进行高效液相色谱分析时作为一种未知化合物被检测到的，通过氧化铝吸附、半制备高效液相色谱和离子交换色谱进行纯化。通过在多个色谱系统中与标准化合物进行比较、通过电化学氧化研究以及通过质谱分析对5-羟基多巴进行了鉴定。
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