Hofvander Y, Hagman U, Linder C E, Vaz R, Slorach S A
Acta Paediatr Scand. 1981 Jan;70(1):3-8. doi: 10.1111/j.1651-2227.1981.tb07164.x.
Individual samples of human milk collected in Uppsala at 3 months post-partum (18 samples) or 6 months post-partum (23 samples) were analysed for chlorinated insecticides and polychlorinated biphenyls (PCBs) by gas chromatography. The mean levels of the organochlorine compounds in the 3- and 6-month groups were similar. The mean content of DDE, the major metabolite of DDT, in all the samples was 54 micrograms/kg fresh weight (1.3 mg/kg on a fat basis) with a range of 8.4--220 micrograms/kg (0.49--3.0 mg/kg fat). The results confirm that the decline since 1967 in the levels of DDT and its metabolites in Swedish human milk reported by other authors is continuing. The levels of dieldrin and beta-hexachlorocyclohexane found are lower than those reported earlier in Sweden, whereas the levels of hexachlorobenzene are about the same. On the other hand, the levels of PCBs (mean 64 micrograms/kg, range 15--150 micrograms/kg, fresh weight, equivalent to 1.6 mg/kg, range 0.84--2.9 mg/kg, on a fat basis) are higher than those reported earlier in Swedish human milk. Although the calculated intake of the DDT complex (DDT + DDE + DDD) by some of the suckling infants exceeds the acceptable daily intake proposed by a FAO/WHO expert group, it does not constitute a reason for recommending any restrictions on breast feeding--for nutritional, immunological and other reasons it should be encouraged.
对在乌普萨拉采集的产后3个月（18份样本）或产后6个月（23份样本）的人乳个体样本，采用气相色谱法分析了其中的氯代杀虫剂和多氯联苯（PCBs）。3个月组和6个月组有机氯化合物的平均水平相似。所有样本中滴滴涕的主要代谢产物DDE的平均含量为54微克/千克鲜重（以脂肪计为1.3毫克/千克），范围为8.4 - 220微克/千克（0.49 - 3.0毫克/千克脂肪）。结果证实，其他作者报道的自1967年以来瑞典人乳中滴滴涕及其代谢产物水平的下降仍在继续。所发现的狄氏剂和β-六氯环己烷的水平低于瑞典此前报道的水平，而六氯苯的水平大致相同。另一方面，多氯联苯的水平（平均64微克/千克，范围15 - 150微克/千克，鲜重，相当于1.6毫克/千克，范围0.84 - 2.9毫克/千克，以脂肪计）高于瑞典此前报道的人乳中的水平。尽管一些哺乳婴儿计算得出的滴滴涕复合物（滴滴涕+DDE+DDD）摄入量超过了粮农组织/世界卫生组织专家组提议的每日可接受摄入量，但这并不构成建议对母乳喂养进行任何限制的理由——出于营养、免疫和其他原因，应鼓励母乳喂养。
