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Irradiation combined with bleomycin treatment of synchronized cells in culture under oxic and hypoxic conditions.

作者信息

Midander J, Littbrand B, Edsmyr F

出版信息

Acta Radiol Oncol. 1980;19(5):395-400. doi: 10.3109/02841868009131325.

DOI:10.3109/02841868009131325
PMID:6163327
Abstract

Bleomycin-treated cells are sensitized to radiation delivered under oxic conditions both in the early S and G2 phases of the cycle, irradiated under hypoxic conditions, sensitization occurs only in the early S phase. This difference in the sensitizing effect of the drug is discussed in regard to the possible clinical advantages of a combined treatment ot tumors with irradiation and Bleomycin.

摘要

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