博来霉素和米索硝唑的细胞毒性。
Bleomycin and misonidazole cytotoxicity.
作者信息
Korbelik M, Palcic B, Skarsgard L D
出版信息
Br J Cancer. 1985 Apr;51(4):499-504. doi: 10.1038/bjc.1985.72.
Abstract
Chinese hamster ovary (CHO) cells were exposed in vitro to combinations of bleomycin and misonidazole under hypoxic conditions. Only one drug was present at any given time and cells were washed before being exposed to the second drug. Both drugs induced potentially lethal damage (PLD). This damage was repaired under hypoxic conditions very rapidly, and bleomycin-induced PLD was repaired more rapidly than misonidazole-induced PLD. If, after the combined treatment, cells are kept in hypoxia, much of the damage can be repaired.
摘要
中国仓鼠卵巢（CHO）细胞在体外低氧条件下暴露于博来霉素和米索硝唑的组合中。在任何给定时间仅存在一种药物，并且在暴露于第二种药物之前对细胞进行洗涤。两种药物均诱导潜在致死性损伤（PLD）。这种损伤在低氧条件下非常迅速地得到修复，并且博来霉素诱导的PLD比米索硝唑诱导的PLD修复得更快。如果在联合治疗后将细胞置于低氧环境中，大部分损伤都可以得到修复。
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