实验性诱导病毒性肠炎期间新生仔猪肠道中的高干扰素滴度
High interferon titer in newborn pig intestine during experimentally induced viral enteritis.
作者信息
La Bonnardiere C, Laude H
出版信息
Infect Immun. 1981 Apr;32(1):28-31. doi: 10.1128/iai.32.1.28-31.1981.
Abstract
We looked for the presence of interferon in the digestive tract of newborn piglets infected with a virulent strain of transmissible gastroenteritis virus (Coronaviridae). High levels of type 1 interferon activity were found early in the disease in jejunal and ileal parts of the intestine as well as in the serum. Enterocytes appeared to be involved in the interferon synthesis. These findings raise the question of the role of interferon in the pathogenesis of viral enteritis.
摘要
我们在感染了强毒株传染性胃肠炎病毒（冠状病毒科）的新生仔猪消化道中寻找干扰素的存在。在疾病早期，在肠道的空肠和回肠部分以及血清中发现了高水平的1型干扰素活性。肠上皮细胞似乎参与了干扰素的合成。这些发现提出了干扰素在病毒性肠炎发病机制中作用的问题。
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