Krilis S, Gregson R P, Basten A, Baldo B A
Int Arch Allergy Appl Immunol. 1981;64(3):293-301. doi: 10.1159/000232706.
19 aspirin-sensitive and 14 non-aspirin-sensitive patients with chronic urticaria were tested for the presence of specific anti-salicyloyl-IgE antibodies by prick testing, RAST and in vitro histamine release using an aspirin-polylysine conjugate. Polylysine succinate served as a control. Negative results were obtained in all cases with the exception of 1 patient who gave a positive prick test response. However, this patient reacted to the control conjugate as well as aspirin polylysine. Skin prick test responses to the battery of environmental allergens revealed that the majority (90%) of the aspirin-sensitive patients were non-atopic. The findings suggest that the clinical symptoms and signs in patients with chronic urticaria associated with aspirin sensitivity are not mediated by specific IgE antibodies.
对19名阿司匹林敏感和14名非阿司匹林敏感的慢性荨麻疹患者，通过点刺试验、放射性变应原吸附试验（RAST）以及使用阿司匹林-聚赖氨酸缀合物进行体外组胺释放试验，检测特异性抗水杨酰-IgE抗体的存在。聚赖氨酸琥珀酸盐用作对照。除1名点刺试验呈阳性反应的患者外，所有病例均得到阴性结果。然而，该患者对对照缀合物和阿司匹林聚赖氨酸均有反应。对一系列环境过敏原的皮肤点刺试验反应显示，大多数（90%）阿司匹林敏感患者为非特应性。研究结果表明，与阿司匹林敏感性相关的慢性荨麻疹患者的临床症状和体征并非由特异性IgE抗体介导。
