Lehmitz R, Olischer R M, Wenk E D
Psychiatr Neurol Med Psychol (Leipz). 1981 Jan;33(1):10-8.
IgG determined by means of quantitative radial immunodiffusion in the cerebrospinal fluid of 225 neurological patients correlates in a statistically significant manner (p less than 0.001) with the gamma-globulin determined by the acetate foil electrophoresis. The indication of the IgG as a percentage of the total protein (limiting value of 10 per cent) is suitable for an orientating assessment in the diagnosis of inflammatory-immunoreactive diseases of the central nervous system. The IgG-values exceeding 10 per cent of the total protein correlate in 260 fluids examined in the respect with the percental value of the lymphocyte content which also lies above the reference range (p less than 0.001). For the assessment of the presence of a barrier disturbance, a comparison with the serum values should be carried out, either in the form of the frequently used fluid/serum quotients of the immunglobulin or the electrophoretically separated protein fraction.
通过定量放射免疫扩散法测定的225例神经系统疾病患者脑脊液中的IgG，与通过醋酸纤维薄膜电泳法测定的γ-球蛋白呈显著统计学相关性（p<0.001）。将IgG表示为总蛋白的百分比（临界值为10%），适用于对中枢神经系统炎症免疫反应性疾病进行初步评估。在检查的260份脑脊液中，IgG值超过总蛋白10%的情况与淋巴细胞含量的百分比值相关，后者也高于参考范围（p<0.001）。为评估血脑屏障是否受损，应将脑脊液值与血清值进行比较，可采用常用的免疫球蛋白脑脊液/血清比值形式，或电泳分离的蛋白组分形式。
