Gerber M A, Thung S N
Am J Clin Pathol. 1981 Apr;75(4):498-503. doi: 10.1093/ajcp/75.4.498.
Hepatocytes with orcein-positive ground-glass cytoplasm have been shown to contain abundant hepatitis B surface antigen in the cisternae of excess smooth endoplasmic reticulum. Hepatocytes with similar cytoplasmic changes that did not react with orcein were observed in 26.5% of 49 cases of cirrhosis. These cells exhibited granular, deeply eosinophilic cytoplasm that stained with phosphotungstic acid-hematoxylin and contained numerous densely packed mitochondria as demonstrated by electron microscopy. Therefore, these cells were designated hepatic oncocytes. They were detected predominantly in cases of established cirrhosis, unrelated to etiology. Hepatic oncocytes may form nodular aggregates, but they did not show evidence of regeneration. The nature and pathogenesis of these cells remain unclear. Because of similar appearance, histochemical stains may be necessary to distinguish ground-glass hepatocytes from hepatic oncocytes.
用orcein染色呈阳性的毛玻璃样细胞质的肝细胞，已被证明在过量滑面内质网的池内含有丰富的乙型肝炎表面抗原。在49例肝硬化病例中，26.5%观察到具有类似细胞质变化但不与orcein反应的肝细胞。这些细胞表现为颗粒状、深嗜酸性细胞质，用磷钨酸苏木精染色，并且电子显微镜显示含有大量紧密堆积的线粒体。因此，这些细胞被命名为肝嗜酸性细胞。它们主要在已确诊的肝硬化病例中检测到，与病因无关。肝嗜酸性细胞可能形成结节状聚集体，但未显示再生迹象。这些细胞的性质和发病机制仍不清楚。由于外观相似，可能需要组织化学染色来区分毛玻璃样肝细胞和肝嗜酸性细胞。
