Shewmon D A, Fine M, Masdeu J C, Palacios E
Ann Neurol. 1981 Apr;9(4):358-65. doi: 10.1002/ana.410090408.
One to 2 weeks after severe brain ischemia, four infants developed an unusual vascular lesion with a characteristic appearance on computed tomography that has not been reported previously. Restricted areas (most frequently the basal ganglia and thalamus) displayed increased attenuation, which enhanced further upon infusion of contrast medium. Autopsy of one infant revealed that the CT abnormality corresponded to an extremely dense neovascular network which had almost completely replaced the parenchyma in that region. We postulate that this pathological change is a stage in the organization of ischemic brain damage reflecting the infant's vascular plasticity. Thus, hypoxia induces marked capillary proliferation in regions of normally high metabolism and capillary density. The CT pattern may prove useful in predicting the location and extent of sequelae to perinatal asphyxia.
严重脑缺血后1至2周，4名婴儿出现了一种不寻常的血管病变，计算机断层扫描显示出特征性表现，此前未见报道。受限区域（最常见于基底神经节和丘脑）显示衰减增加，注入造影剂后进一步增强。对一名婴儿进行尸检发现，CT异常对应于一个极其密集的新生血管网络，该区域的实质几乎完全被其取代。我们推测这种病理变化是缺血性脑损伤组织化过程中的一个阶段，反映了婴儿的血管可塑性。因此，缺氧会在正常代谢率高和毛细血管密度高的区域诱导明显的毛细血管增生。这种CT表现可能有助于预测围产期窒息后遗症的位置和程度。
