van der Kooy D, Carter D A
Brain Res. 1981 Apr 27;211(1):15-36. doi: 10.1016/0006-8993(81)90064-0.
Multiple retrograde fluorescent tracing was employed to investigate the organization of the rat entopeduncular nucleus projections to the lateral habenula, ventral anterior-ventral lateral thalamus, parafasicular-centre median complex, and tegmenti pedunculopontis area of the brain stem. The results indicate that neurons in the rostral 2/3 of the entopeduncular nucleus project to the lateral habenula. In contrast, neurons in the caudal 1/3 of the entopeduncular nucleus project to the ventral anterior-ventral lateral thalamus, parafasicular-centre median complex, and tegmenti pedunculopontis area of the brain stem. The majority of neurons in the caudal 1/3 of the entopeduncular nucleus are retrogradely double-labeled from various combinations of tracer injections into the 3 termination areas to which they projected. Little or no retrograde labeling in the entopeduncular nucleus was produced by tracer injections in the substantia nigra or subthalamic nucleus. Only large injections of tracers in the tegmenti pedunculopontis are and the surrounding brain stem produced retrograde labeling in the entopeduncular nucleus. These brain stem injections also labeled a band of cells surrounding the entopeduncular nucleus in the zona incerta, lateral hypothalamus, of the ansa lenticularis and central nucleus of the amygdala. [3H]Leucine injections in the head of the caudate-putamen complex (but not in the cortex or globus pallidus) produced dense accumulations of silver grains over both the rostral and caudal portions of the entopeduncular nucleus. [3H]Leucine injections in the caudal body of the caudate-putamen complex produced accumulations of silver grains over a "ventral entopeduncular nucleus area' in the nucleus of the ansa peduncularis. It was suggested that the head of the striatum projects both to the neurons of the rostral "limbic' portion of the entopeduncular nucleus, which project to the lateral habenula, and to the neurons of the caudal "motor' portion of the entopeduncular nucleus, which project primarily by way of axon collaterals to the ventral anterior-ventral lateral thalamus, parafascicular-centre median complex, and tegmenti pedunculopontis area of the brain stem.
采用多次逆行荧光追踪法研究大鼠内苍白球核向外侧缰核、丘脑腹前-腹外侧核、束旁-中央中复合体以及脑干脚桥被盖区的投射组织。结果表明，内苍白球核嘴侧2/3的神经元投射至外侧缰核。相反，内苍白球核尾侧1/3的神经元投射至丘脑腹前-腹外侧核、束旁-中央中复合体以及脑干脚桥被盖区。内苍白球核尾侧1/3的大多数神经元从向其投射的3个终末区域的各种示踪剂注射组合中被逆行双标记。在黑质或丘脑底核注射示踪剂在内苍白球核中产生很少或没有逆行标记。仅在脚桥被盖区及其周围脑干进行大量示踪剂注射才在内苍白球核中产生逆行标记。这些脑干注射还标记了未定带、外侧下丘脑、豆状袢和杏仁核中央核中围绕内苍白球核的一圈细胞。在尾壳核复合体头部注射[3H]亮氨酸（但不在皮质或苍白球）在内苍白球核的嘴侧和尾侧部分均产生密集的银粒聚集。在尾壳核复合体尾部注射[3H]亮氨酸在脚桥核中一个“腹侧内苍白球核区域”产生银粒聚集。有人提出，纹状体头部既投射至内苍白球核嘴侧“边缘”部分的神经元（这些神经元投射至外侧缰核），也投射至内苍白球核尾侧“运动”部分的神经元（这些神经元主要通过轴突侧支投射至丘脑腹前-腹外侧核、束旁-中央中复合体以及脑干脚桥被盖区）。
