Georgiev G P, Il'in Iu V, Ryskov A P, Kramerov D A
Genetika. 1981;17(2):222-32.
During last three years, the mobile dispersed genetic elements (mdg) were isolated from the genome of Drosophila melanogaster, yeasts and mammals. According to a number of their properties, mdg elements are quite similar to endogenous pro-retroviruses. It is known that in many cases oncogeneity of retroviruses depends on the incorporation of the certain host genes (potential oncogenes) into the viral genome. We suggest that in some cases mdg elements could entrap the potential oncogenes in the course of transposition. As a result, oncogenes become uncontrollable by host regulatory systems and may induce cell transformation. Another possible mechanism underlying switch off of the gene responsible for differentiation control may be mdg transposition to a region in close vicinity of the gene. As transposition of mdg elements seems to occur rather often, they may be regarded as one of the most important factors of genome rearrangements leading to cell transformation.
在过去三年中，从黑腹果蝇、酵母和哺乳动物的基因组中分离出了移动分散遗传元件（mdg）。根据它们的一些特性，mdg元件与内源性前逆转录病毒非常相似。众所周知，在许多情况下，逆转录病毒的致癌性取决于某些宿主基因（潜在致癌基因）整合到病毒基因组中。我们认为，在某些情况下，mdg元件在转座过程中可能会捕获潜在致癌基因。结果，致癌基因变得不受宿主调节系统控制，并可能诱导细胞转化。负责分化控制的基因关闭的另一个可能机制可能是mdg转座到该基因附近的区域。由于mdg元件的转座似乎经常发生，它们可能被视为导致细胞转化的基因组重排的最重要因素之一。
