Schönbeck C, Björck L, Kronvall G
Infect Immun. 1981 Mar;31(3):856-61. doi: 10.1128/iai.31.3.856-861.1981.
Binding of radiolabeled human fibrinogen and aggregated beta-microglobulin was measured in 60 strains of beta-hemolytic group B streptococci. Positive fibrinogen binding was detected in seven of the strains. Six of the group B strains showed an uptake of aggregated beta 2-microglobulin. Four individual strains carried both receptors, indicating a positive correlation between their occurrence. Inhibition studies showed that fibrinogen competed sterically with beta 2-microglobulin binding. Receptors for both proteins were trypsin sensitive. The presence of receptors did not correlate with the serological type of the 49 group B strains tested. However, all seven type II strains were negative. No uptake of fibrinogen was noted in any of 40 group D strains tested. Binding structures for fibrinogen and aggregated beta 2-microglobulin detected in group B streptococci were similar to receptors for the same proteins in group A, C, and G streptococci in terms of mutual correlation and steric interference of binding. The occasional occurrence of these receptors also in group B strains might reflect a common origin of some types of surface proteins in gram-positive cocci.
在60株B族溶血性链球菌中检测了放射性标记的人纤维蛋白原和聚集的β-微球蛋白的结合情况。在7株菌株中检测到纤维蛋白原结合呈阳性。6株B族菌株显示摄取了聚集的β2-微球蛋白。4株单独的菌株同时具有这两种受体，表明它们的出现之间存在正相关。抑制研究表明，纤维蛋白原在空间上与β2-微球蛋白的结合竞争。两种蛋白质的受体对胰蛋白酶敏感。受体的存在与所测试的49株B族菌株的血清型无关。然而，所有7株II型菌株均为阴性。在测试的40株D族菌株中，未观察到任何纤维蛋白原的摄取。就结合的相互相关性和空间干扰而言，在B族链球菌中检测到的纤维蛋白原和聚集的β2-微球蛋白的结合结构与A、C和G族链球菌中相同蛋白质的受体相似。这些受体在B族菌株中的偶尔出现可能反映了革兰氏阳性球菌某些类型表面蛋白的共同起源。
