Martin M R
J Comp Neurol. 1981 Mar 20;197(1):141-52. doi: 10.1002/cne.901970111.
The morphology of the cochlear nuclei of normal and reeler mutant mice were studied in Nissl-stained sections. The cochlear nucleus in both mice is divisible into three parts: the anteroventral, posteroventral, and dorsal nuclei. Nine cell types can be recognized in the normal mouse. In the anteroventral nucleus spherical cells occupy the rostral pole. Globular cells are located caudally and extend to the interstitial region of the anteroventral nucleus. In the posteroventral nucleus multipolar cells are located rostrally and dark-staining cells occupy the caudal pole. Multipolar cells are also present in the anteroventral nucleus and in the deep region and molecular layer of the dorsal cochlear nucleus. The dorsal and lateral aspects of the ventral nuclei are covered by a granule cell layer. The dorsal nucleus consists of superficial molecular and pyramidal layers and a deep region. The deep region contains small and giant cells as well as multipolar cells. The pyramidal layer is made up of pyramidal cells, horizontal cells, and granule cells. Small cells are also present in the molecular layer and throughout the ventral nuclei. The dorsal cochlear nucleus of the reeler mutant mouse is disorganized and the molecular layer is reduced in thickness. The organization of the pyramidal layer is disrupted with granule cells superficial to pyramidal and horizontal cells. Cells which appear to be homologous to pyramidal cells are also present in the deep region of the dorsal nucleus. The total number of granule cells is reduced by an average of 42% over the whole nucleus and the reduction in granule cells is greatest in the granule cell cap covering the dorsal and lateral surface of the ventral cochlear nuclei. The cytoarchitecture of the ventral cochlear nucleus appears normal.
在尼氏染色切片中研究了正常小鼠和reeler突变小鼠耳蜗核的形态。两种小鼠的耳蜗核均可分为三部分：前腹侧核、后腹侧核和背侧核。正常小鼠中可识别出九种细胞类型。在前腹侧核中，球形细胞占据吻侧极。球状细胞位于尾侧并延伸至前腹侧核的间质区域。在后腹侧核中，多极细胞位于吻侧，深色染色细胞占据尾侧极。多极细胞也存在于前腹侧核以及背侧耳蜗核的深部区域和分子层。腹侧核的背侧和外侧被颗粒细胞层覆盖。背侧核由浅分子层、锥体细胞层和深部区域组成。深部区域包含小细胞、巨细胞以及多极细胞。锥体细胞层由锥体细胞、水平细胞和颗粒细胞组成。小细胞也存在于分子层以及整个腹侧核中。reeler突变小鼠的背侧耳蜗核结构紊乱，分子层厚度减小。锥体细胞层的组织被破坏，颗粒细胞位于锥体细胞和水平细胞的浅层。在背侧核的深部区域也存在似乎与锥体细胞同源的细胞。整个核内颗粒细胞总数平均减少42%，颗粒细胞减少最多的是覆盖腹侧耳蜗核背侧和外侧表面的颗粒细胞帽。腹侧耳蜗核的细胞结构看起来正常。
