结肠癌切除术后已知存在残留病灶患者的癌胚抗原评估
Evaluation of CEA in patients with known residual disease after resection of colonic cancer.
作者信息
Lawton J O, Giles G R, Cooper E H
出版信息
J R Soc Med. 1980 Jan;73(1):23-8. doi: 10.1177/014107688007300106.
Serial carcinoembryonic antigen (CEA) levels were measured in 43 patients following incomplete excision of colorectal cancer. Twenty-seven patients received chemotherapy. In the majority the subsequent elevation of CEA could be related to clinical progression, but some patients receiving chemotherapy may have a suppressed rate of CEA rise and may have a more prolonged survival.The clinical application of serial CEA estimations remains of dubious value. However, one area which may be worthy of study is to determine whether suppression of the CEA slope by chemotherapy is attended by clinical control and an improved survival.
对43例结直肠癌切除不完全的患者进行了癌胚抗原（CEA）水平的连续检测。27例患者接受了化疗。大多数情况下，随后CEA的升高可能与临床进展有关，但一些接受化疗的患者CEA升高速率可能受到抑制，生存期可能更长。连续CEA检测的临床应用价值仍存疑问。然而，一个可能值得研究的领域是确定化疗对CEA斜率的抑制是否伴随着临床控制和生存期的延长。
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