Laurence D J, Neville A M
Cancer Metastasis Rev. 1983;2(4):351-74. doi: 10.1007/BF00048567.
Many biochemical indices are purported to have clinical utility in the detection and management of neoplasia. Experience gained during the past decade tends to indicate their having a more important role in the detection and monitoring of metastases than of the primary lesion. From this present review of some of the commoner human tumours, it is concluded that such marker substances are important adjuncts in the management of germ cell and certain endocrine and endocrine-related tumours. The carcinoembryonic antigen (CEA) provides a marker for many gastrointestinal cancers, but there are no presently available substances with clinical usefulness for either breast or lung neoplasms. Alternative approaches to the detection of metastases are also presented. The particular use of antibody probes at an immunohistochemical level has been claimed to be able to detect micrometastastic disease in bone marrow or tumour-related monoclonal antibody probes may have application to other cancers in the future.
许多生化指标据称在肿瘤的检测和管理中具有临床应用价值。过去十年所积累的经验倾向于表明，它们在转移灶的检测和监测中所起的作用比在原发性病变中更为重要。从本次对一些较常见人类肿瘤的综述中可以得出结论，此类标志物物质在生殖细胞肿瘤以及某些内分泌和内分泌相关肿瘤的管理中是重要的辅助手段。癌胚抗原（CEA）是许多胃肠道癌症的标志物，但目前尚无对乳腺癌或肺癌具有临床应用价值的物质。文中还介绍了检测转移灶的其他方法。有人声称，在免疫组织化学水平上使用抗体探针能够检测骨髓中的微转移疾病，或者与肿瘤相关的单克隆抗体探针未来可能应用于其他癌症。
