Hardy S G, Leichnetz G R
Neurosci Lett. 1981 Mar 10;22(2):97-101. doi: 10.1016/0304-3940(81)90070-7.
Stereotaxic fluid microinjections of horseradish peroxidase (HRP) into the periaqueductal gray (PAG), coupled with cortical HRP gel placements in macaque and cebus monkeys, have provided substantive retrograde and orthograde evidence that the rostral dorsal convexity and rostral medial prefrontal cortex are the principal sources of cortical-PAG projections. The prefrontal cortex projects to the dorsolateral quadrant of the PAG, precisely the area shown to receive spinothalamic inputs in mammals, including monkey. The findings are discussed in terms of a possible affective role in central analgesic mechanisms.
将辣根过氧化物酶（HRP）立体定向微量注射到中脑导水管周围灰质（PAG），并结合在猕猴和僧帽猴中放置皮质HRP凝胶，已提供了实质性的逆行和顺行证据，表明吻侧背凸和吻侧内侧前额叶皮层是皮质 - PAG投射的主要来源。前额叶皮层投射到PAG的背外侧象限，正是在包括猴子在内的哺乳动物中显示接受脊髓丘脑输入的区域。从在中枢镇痛机制中可能的情感作用方面对这些发现进行了讨论。
