Christensen C K, Mogensen C E, Hanberg Sørensen F
Scand J Gastroenterol. 1981;16(1):129-34.
Urinary albumin and beta 2-microglobulin excretion and creatinine clearance were measured during 8 weeks' conventional cimetidine treatment in 13 ulcer patients without signs of renal disease. No changes were found in albumin or in beta 2-microglobulin excretion, indicating no changes in glomerular permeability and tubular reabsorption of proteins in the kidney. Creatinine clearance fell about 28 ml/min (26%) during cimetidine treatment but normalized after termination of medication. Concomitantly, serum creatinine increased by 22% during treatment and fell again after termination of treatment. The mechanism behind the changes in renal handling of creatinine during cimetidine was not clarified in the present study. It is concluded that the conventional 8 weeks' cimetidine treatment seems safe from the renal point of view, at least in patients without signs of renal disease.
在13例无肾脏疾病迹象的溃疡患者接受8周常规西咪替丁治疗期间，测定了尿白蛋白、β2-微球蛋白排泄量及肌酐清除率。白蛋白或β2-微球蛋白排泄量未发现变化，表明肾脏的肾小球通透性和蛋白质的肾小管重吸收没有改变。西咪替丁治疗期间肌酐清除率下降约28 ml/min（26%），但停药后恢复正常。同时，治疗期间血清肌酐升高22%，停药后再次下降。本研究未阐明西咪替丁治疗期间肌酐肾脏处理变化背后的机制。结论是，从肾脏角度来看，至少在无肾脏疾病迹象的患者中，常规8周的西咪替丁治疗似乎是安全的。
