黑猩猩的混合淋巴细胞反应。II. 家系研究及D位点抗原的鉴定

Mixed lymphocyte reactivity in chimpanzees. II. Family studies and identification of D locus antigens.

作者信息

Jonker M, Balner H

出版信息

Tissue Antigens. 1981 Feb;17(2):179-94. doi: 10.1111/j.1399-0039.1981.tb00682.x.

DOI:10.1111/j.1399-0039.1981.tb00682.x

Abstract

A large number of related chimpanzees were tested in mixed lymphocyte cultures against each other. Several similarities among the D locus products coded for by different ChLA haplotypes were observed. Six animals were found to be homozygous for D locus antigens and two of these animals carried the same D specificity. Hence, the available "typing cells" permitted the identification of five D locus antigens of the chimpanzee. So far, no linkage disequilibrium has been found between any of the D locus antigens and ChLA-A or -B locus antigens.

摘要

对大量相关黑猩猩进行了混合淋巴细胞培养相互测试。观察到不同ChLA单倍型编码的D位点产物之间有几个相似之处。发现6只动物的D位点抗原是纯合的，其中2只动物具有相同的D特异性。因此，现有的“分型细胞”能够识别黑猩猩的5种D位点抗原。到目前为止，尚未发现任何D位点抗原与ChLA - A或 - B位点抗原之间存在连锁不平衡。