恒河猴的RhLA复合体。X. D与Ia1位点抗原之间关联的意义。
RhLA complex of Rhesus monkeys. X. Implications of the association between D and Ia1 locus antigens.
作者信息
van Es A A, Balner H
出版信息
Tissue Antigens. 1978 Oct;12(4):279-96. doi: 10.1111/j.1399-0039.1978.tb01336.x.
A high association has been found between D-locus determinants defined by cellular methods (typing cells) and the serologically defined B cell or Ia antigens controlled by the Ia1 locus. Data from recombinant offspring in two rhesus families place the Ia1 locus within RhLA, in the close vicinity of the D or major MLC locus. In fact, identity between the products of those two loci cannot be excluded. Further, it was shown that cells proven to be homozygous for Ia1 antigens, are nearly always typing cells (and therefore homozygous for D-locus determinants) and, conversely, that proven typing cells carry only a single Ia1 antigen and are thus probably homozygous for Ia1 products. In addition, it could be demonstrated that matching for Ia1 antigens greatly facilitates the detection of unrelated individuvals who are mutually non-reactive in MLC. This "predictive value" of Ia1 matching has important implications for the selection of optimal donors for organ transplantation.
通过细胞方法（分型细胞）定义的D位点决定簇与由Ia1位点控制的血清学定义的B细胞或Ia抗原之间已发现高度关联。来自两个恒河猴家族重组后代的数据将Ia1位点定位在RhLA内，紧邻D或主要MLC位点。事实上，不能排除这两个位点的产物之间的一致性。此外，研究表明，被证明对Ia1抗原纯合的细胞几乎总是分型细胞（因此对D位点决定簇纯合），相反，被证明的分型细胞仅携带单一Ia1抗原，因此可能对Ia1产物纯合。此外，可以证明，Ia1抗原匹配极大地促进了在MLC中相互无反应的无关个体的检测。Ia1匹配的这种“预测价值”对器官移植最佳供体的选择具有重要意义。
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