Meier U, Wolff F, Fischer J H, Klingspohr H J, Bolte A
Z Geburtshilfe Perinatol. 1980 Feb;184(1):11-6.
Fenoterol induced displacements of the fetal oxygen dissociation curve were investigated in animal experiments by determining the oxygen halfsaturation pressure (P 50). At term pregnant rabbits were infused intravenously over 3 hours with an increasing Fenoterol dosis (10 to 30 microgram/kg/min) up to a dosis level which produced complete labour inhibition. By cesarean section fetal aortic blood was collected and the oxygen halfsaturation pressure (P 50) was determined as described by Lichtman et al. (14). All P 50 values were corrected to so-called standard conditions (pH: 7.4; PCO2: 40 mmHg; t: 37 degrees C). Likewise, in a second series P 50 values were measured in newborn rabbits which received Fenoterol subcutaneously as a single shot injection. In the first series standardized P 50 significantly fell from 20.9 to 15.0 mmHg and in the second series it fell from 20.9 to 14.4 mmHg. This raised oxygen hemoglobin affinity, i.e. leftward shift of the fetal oxygen dissociation curve, is probably due to a Fenoterol induced diminution of the red cell 2.3-DPG concentration. In all cases of severe fetal hypoxia a beneficial effect on O2-transport is discussed whereas at normoxia or mild hypoxia a rightward shift of the oxygen dissociation curve would be more favourable.
在动物实验中，通过测定氧半饱和压力（P50）研究了非诺特罗对胎儿氧解离曲线的影响。对足月妊娠兔静脉输注非诺特罗剂量递增（10至30微克/千克/分钟），持续3小时，直至达到完全抑制分娩的剂量水平。通过剖宫产收集胎儿主动脉血，并按照利希特曼等人（14）所述方法测定氧半饱和压力（P50）。所有P50值均校正至所谓的标准条件（pH：7.4；PCO2：40 mmHg；温度：37摄氏度）。同样，在第二个系列中，对单次皮下注射非诺特罗的新生兔测量P50值。在第一个系列中，标准化P50从20.9 mmHg显著降至15.0 mmHg，在第二个系列中从20.9 mmHg降至14.4 mmHg。这种氧血红蛋白亲和力增加，即胎儿氧解离曲线左移，可能是由于非诺特罗导致红细胞2,3 -二磷酸甘油酸（2,3-DPG）浓度降低所致。在所有严重胎儿缺氧的情况下，讨论了其对氧运输的有益作用，而在正常氧合或轻度缺氧时，氧解离曲线右移可能更有利。
