各种干扰素种类之间的抗原关系。

Antigenic relationships among various interferon species.

作者信息

Kawade Y, Yamamoto Y, Fujisawa J, Watanabe Y

出版信息

Ann N Y Acad Sci. 1980;350:422-7. doi: 10.1111/j.1749-6632.1980.tb20644.x.

DOI:10.1111/j.1749-6632.1980.tb20644.x

Abstract

Mouse L-cell interferon consists of two antigenically distinct species, F (22 to 24K) and S(32 to 40K). Various type I mouse interferons, regardless of lymphoid or nonlymphoid origin, likewise consist of two species, whose antigenicities are indistinguishable from the two L-cell interferons. Interferon F was found to be completely neutralizable by an antiserum against human leukocyte interferon, suggesting a structural similarity between the important species of human and mouse interferons.

摘要

小鼠L细胞干扰素由两种抗原性不同的类型组成，即F型（22至24K）和S型（32至40K）。各种I型小鼠干扰素，无论其来源是淋巴细胞还是非淋巴细胞，同样由两种类型组成，其抗原性与两种L细胞干扰素无法区分。已发现干扰素F可被抗人白细胞干扰素的抗血清完全中和，这表明人和小鼠重要类型的干扰素之间存在结构相似性。