人淋巴母细胞干扰素的抗原特性
Antigenic properties of human lymphoblastoid interferons.
作者信息
Dalton B J, Paucker K
出版信息
Infect Immun. 1979 Feb;23(2):244-8. doi: 10.1128/iai.23.2.244-248.1979.
Abstract
Most virus-induced human lymphoblastoid interferons examined contained variable proportions of the Le and F antigenic species described for human leukocyte interferon. The F species was not detectable in interferons liberated spontaneously from human lymphoblastoid cells in culture. Lymphoblastoid interferons differed considerably in their interaction with the same anti-interferon serum. Spontaneous interferons required approximately ten times less antibody for neutralization than interferon induced by virus in the same cultures or in Namalva cells. The findings suggest that either spontaneous interferons contain fewer inactive antibody-binding molecules than virus-induced lymphoblastoid interferons or the number and distribution of antibody-combining sites, and possibly other surface properties of the interferon molecule, may be influenced by the manner in which spontaneous and induced interferons egress from the cells.
摘要
大多数检测的病毒诱导的人淋巴母细胞干扰素含有不同比例的、针对人白细胞干扰素所描述的Le和F抗原种类。在培养的人淋巴母细胞中自发释放的干扰素中检测不到F种类。淋巴母细胞干扰素与同一种抗干扰素血清的相互作用差异很大。与在相同培养物中或Namalva细胞中由病毒诱导的干扰素相比，自发干扰素中和所需的抗体量大约少十倍。这些发现表明，要么自发干扰素含有的无活性抗体结合分子比病毒诱导的淋巴母细胞干扰素少，要么抗体结合位点的数量和分布，以及干扰素分子可能的其他表面特性，可能受自发和诱导干扰素从细胞中释放方式的影响。
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