Mosko S S, Pierce S, Holowach J, Sassin J F
Electroencephalogr Clin Neurophysiol. 1981 May;51(5):477-82. doi: 10.1016/0013-4694(81)90224-8.
Brain stem auditory evoked potentials (BAEPs) can be utilized as an index of neuronal dysfunction at the level of the brain stem. These waves are known to be independent of level of arousal. In the present study, BAEPs (waves I-V) to monaural click stimulation were recorded during daytime waking and as a function of arterial oxygen saturation during nocturnal sleep in 6 subjects with obstructive sleep apnea syndrome. Normal conduction times were recorded in all 6 subjects during daytime waking. In addition, BAEPs remained stable in every case during sleep-related apneas when averaged over intervals of arterial oxygen saturation as low as 45-70% in one subject. Our data indicate that (1) the repetitive oxygen desaturation experienced during sleep in apneics had neither acute nor chronic, measurable effects on neurons which subserve the BAEP, and (2) a brain stem abnormality involving the structures which subserve the BAEP does not underly obstructive sleep apnea.
脑干听觉诱发电位（BAEPs）可作为脑干水平神经元功能障碍的一个指标。已知这些波与觉醒水平无关。在本研究中，对6名阻塞性睡眠呼吸暂停综合征患者在白天清醒时记录了单耳短声刺激的BAEPs（波I-V），并记录了夜间睡眠期间作为动脉血氧饱和度函数的BAEPs。在所有6名受试者白天清醒时均记录到正常的传导时间。此外，在一名受试者中，当动脉血氧饱和度低至45%-70%的间隔内平均时，BAEPs在与睡眠相关的呼吸暂停期间在每种情况下都保持稳定。我们的数据表明：（1）呼吸暂停患者睡眠期间经历的重复性氧饱和度下降对产生BAEP的神经元既没有急性也没有慢性的可测量影响；（2）涉及产生BAEP的结构的脑干异常并非阻塞性睡眠呼吸暂停的基础。
