Mosko S S, Knipher K F, Sassin J F, Donnelly J
Sleep. 1984;7(3):239-46. doi: 10.1093/sleep/7.3.239.
In adults with obstructive sleep apnea middle latency auditory evoked responses were recorded as a function of apnea-related arterial oxygen desaturation both before sleep onset and during nocturnal sleep. In waking, wave Pa latency was normal in five of six subjects, and Pa amplitude was normal in all. During sleep apneas, wave Pa remained stable even during intervals of severe oxygen desaturation (e.g., 45-90% and 50-84% saturation in two subjects). Furthermore, wave Pa recorded immediately on awakening in the morning was unaltered compared with the response recorded just prior to sleep onset, despite a high frequency of nocturnal apneas in all subjects. These data indicate that repetitive nocturnal oxygen desaturation associated with severe obstructive sleep apnea syndrome has neither immediate nor cumulative measureable effects on the functioning of neurons that subserve the middle latency evoked response. These findings are discussed in relation to a possible cortical contribution to the middle latency response.
在患有阻塞性睡眠呼吸暂停的成年人中，记录了睡眠开始前和夜间睡眠期间与呼吸暂停相关的动脉血氧饱和度函数的中潜伏期听觉诱发电位。在清醒状态下，六名受试者中有五名的Pa波潜伏期正常，所有受试者的Pa波振幅均正常。在睡眠呼吸暂停期间，即使在严重氧饱和度下降的时间段（例如，两名受试者的饱和度分别为45 - 90%和50 - 84%），Pa波仍保持稳定。此外，尽管所有受试者夜间呼吸暂停频率很高，但早晨醒来后立即记录的Pa波与睡眠开始前记录的反应相比没有变化。这些数据表明，与严重阻塞性睡眠呼吸暂停综合征相关的重复性夜间氧饱和度下降对参与中潜伏期诱发电位的神经元功能既没有即时影响也没有累积的可测量影响。结合对中潜伏期反应可能的皮质贡献对这些发现进行了讨论。
