Ueda G, Yamasaki M, Inoue M, Tanaka Y, Kurachi K
Nihon Sanka Fujinka Gakkai Zasshi. 1980 Jul;32(7):960-4.
Sixteen endometrial carcinomas were studied by an immunoperoxidase method with anti-human calcitonin, 8 with and 8 without argyrophil cells. Calcitonin was demonstrated in 7 with and 2 without argyrophil cells. Calcitonin production was not associated with any specific histology of the endometrial carcinomas. Regardless of the existence of argyrophil cells, calcitonin was located in the apical portion or in the entire cytoplasm of the glandular tumor cells in the well differentiated adenocarcinomas. In a poorly differentiated adenocarcinoma and the adenosquamous carcinomas, it was found in many immature and squamous tumor cells as well as in some glandular tumor cells. The comparative studies between calcitonin and argyrophil granules in the endometrial carcinomas with argyrophil cells revealed that calcitonin was located in many tumor cells other than argyrophil cells. The extreme examples were 2 calcitonin-producing tumors without argyrophil cells. Calcitonin production of the endometrial carcinomas is a novel finding, but the biological significance of argyrophil cells remains to be further investigated.
采用抗人降钙素免疫过氧化物酶法对16例子宫内膜癌进行了研究，其中8例有嗜银细胞，8例无嗜银细胞。7例有嗜银细胞的病例和2例无嗜银细胞的病例中检测到降钙素。降钙素的产生与子宫内膜癌的任何特定组织学类型均无关联。无论有无嗜银细胞，在高分化腺癌中，降钙素位于腺性肿瘤细胞的顶端部分或整个细胞质中。在低分化腺癌和腺鳞癌中，在许多未成熟和鳞状肿瘤细胞以及一些腺性肿瘤细胞中也发现了降钙素。对有嗜银细胞的子宫内膜癌中降钙素和嗜银颗粒的比较研究表明，降钙素存在于嗜银细胞以外的许多肿瘤细胞中。极端的例子是2例无嗜银细胞但产生降钙素的肿瘤。子宫内膜癌产生降钙素是一项新发现，但嗜银细胞的生物学意义仍有待进一步研究。
