Ueda G, Yamasaki M, Inoue M, Tanaka Y, Inoue Y, Abe Y, Tanizawa O
Int J Gynecol Pathol. 1986;5(2):143-50.
Gynecologic tumors with argyrophilia were tested immunohistochemically for reactivity with monoclonal antibody HNK-1, which detects normal and neoplastic cells derived from the neuroectodermal and the amine-precursor-uptake and decarboxylation (APUD) systems. The tumors included six small cell carcinomas and four adenocarcinomas of the cervix; 23 adenocarcinomas of the endometrium (13 with type I and 10 with type II argyrophil cells); and 11 mucinous tumors (three benign, three borderline, and five malignant), eight endometrioid carcinomas (four with type I and four with type II argyrophil cells), and two carcinoid tumors (one insular and one strumal) of the ovary. HNK-1 reactive cells were found in almost every category of tumor: in four small cell carcinomas and two adenocarcinomas of the cervix; 11 adenocarcinomas of the endometrium (eight with type I and three with type II argyrophil cells); and four mucinous (two benign and two borderline), two endometrioid (one with type I and one with type II argyrophil cells), and two carcinoid tumors of the ovary. These cells corresponded to at least some of the type I argyrophil cells in endometrial and ovarian endometrioid carcinomas and to similar cells in mucinous and carcinoid tumors of the ovary and small cell carcinoma and adenocarcinoma of the cervix. However, the remaining type I and similar argyrophil cells and almost all type II argyrophil cells were HNK-1 negative, and some of the nonargyrophil tumor cells were HNK-1 positive. Although the significance of such discrepancies in reactivity with HNK-1 antibody remains unknown, the present results suggest that some of the gynecologic tumors with argyrophilia are related to APUDomas.
对具有嗜银性的妇科肿瘤进行免疫组织化学检测，以检测其与单克隆抗体HNK-1的反应性，该抗体可检测源自神经外胚层以及胺前体摄取和脱羧（APUD）系统的正常细胞和肿瘤细胞。这些肿瘤包括6例宫颈小细胞癌和4例腺癌；23例子宫内膜腺癌（13例含I型嗜银细胞，10例含II型嗜银细胞）；11例黏液性肿瘤（3例良性、3例交界性和5例恶性）、8例子宫内膜样癌（4例含I型嗜银细胞，4例含II型嗜银细胞）以及2例卵巢类癌肿瘤（1例岛状和1例甲状腺肿样）。几乎在每种肿瘤类型中都发现了HNK-1反应性细胞：4例宫颈小细胞癌和2例腺癌；11例子宫内膜腺癌（8例含I型嗜银细胞，3例含II型嗜银细胞）；4例黏液性肿瘤（2例良性和2例交界性）、2例子宫内膜样癌（1例含I型嗜银细胞，1例含II型嗜银细胞）以及2例卵巢类癌肿瘤。这些细胞对应于子宫内膜和卵巢子宫内膜样癌中至少部分I型嗜银细胞，以及卵巢黏液性和类癌肿瘤、宫颈小细胞癌和腺癌中的类似细胞。然而，其余I型及类似嗜银细胞以及几乎所有II型嗜银细胞均为HNK-1阴性，一些非嗜银性肿瘤细胞为HNK-1阳性。尽管与HNK-1抗体反应性存在这种差异的意义尚不清楚，但目前的结果表明，一些具有嗜银性的妇科肿瘤与APUD瘤有关。
