Aleo J J
J Periodontol. 1981 May;52(5):251-4. doi: 10.1902/jop.1981.52.5.251.
An hypothesis is proposed relating the possible role of vitamin deficiency as an etiologic factor contributing to periodontal disease in diabetes. The hypothesis is based upon the following: (1) transport of ascorbate across cell membranes may be impaired by glucose, but facilitated by insulin; (2) glucose utilization is significantly accelerated by sublethal concentrations of endotoxin; (3) endotoxin-induced histamine sensitivity of tissue is enhanced by ascorbic deficiency; and (4) ascorbic acid deficiency alters mucosal barrier function. The interrelationship of these factors is discussed.
提出了一种假说，该假说涉及维生素缺乏作为导致糖尿病患者牙周病的病因因素的可能作用。该假说基于以下几点：（1）葡萄糖可能会损害抗坏血酸盐跨细胞膜的转运，但胰岛素可促进其转运；（2）亚致死浓度的内毒素可显著加速葡萄糖的利用；（3）抗坏血酸缺乏会增强内毒素诱导的组织对组胺的敏感性；（4）抗坏血酸缺乏会改变黏膜屏障功能。讨论了这些因素之间的相互关系。
