Ginter E, Zdichynec B, Holzerová O, Tichá E, Kobza R, Koziaková M, Cerná O, Ozdín L, Hrubá F, Nováková V, Sasko E, Gaher M
Int J Vitam Nutr Res. 1978;48(4):368-73.
A significantly lower vitamin C concentration has been found in the blood and particularly in the leukocytes of hypercholesterolemic diabetic patients than of healthy blood donors. Ascorbic acid administered in a dose of 500 mg per day for 12 months to metabolically stabilized hypercholesterolemic subjects with maturity-onset diabetes mellitus (diabetic diet without insulin or diabetic drugs) brought about a striking decline of cholesterolemia and a moderate decline of triglyceridemia. The serum lipid level in the control group given placebo remained unaltered. A daily administration of 500 mg of ascorbic acid for six months failed to affect the fasting level of serum immunoreactive insulin. It is assumed that the long-term administration of ascorbic acid to maturity-onset diabetics removed the tissue ascorbate deficiency and improved the liver ability to compensate the increased endogenous synthesis of cholesterol by its enhanced transformation to bile acids.
已发现，与健康献血者相比，高胆固醇血症糖尿病患者血液中，尤其是白细胞中的维生素C浓度显著降低。对于患有成年型糖尿病且代谢稳定的高胆固醇血症患者（采用无糖或无糖尿病药物的糖尿病饮食），每天服用500毫克抗坏血酸，持续12个月，可使胆固醇血症显著下降，甘油三酯血症适度下降。给予安慰剂的对照组血清脂质水平未发生变化。每日服用500毫克抗坏血酸，持续六个月，未能影响血清免疫反应性胰岛素的空腹水平。据推测，长期给成年型糖尿病患者服用抗坏血酸可消除组织中抗坏血酸盐缺乏的情况，并通过增强其向胆汁酸的转化来提高肝脏补偿内源性胆固醇合成增加的能力。
