Kwok Y H, Mitchelson F
Naunyn Schmiedebergs Arch Pharmacol. 1981 Apr;316(2):161-4. doi: 10.1007/BF00505311.
The antimuscarinic activity of mianserin and amitriptyline was investigated in the cat superior cervical ganglion using McN-A-343 as a muscarinic agonist. Mianserin was found to have a similar order of potency to amitriptyline in this preparation, in contrast to the marked difference in their antimuscarinic activities on non-neuronal muscarinic receptors. These findings suggest that the action of mianserin on neuronal muscarinic receptors is more important than that predicted from studies on non-neuronal receptors and may be related to its anti-depressant activity.
以 McN-A-343 作为毒蕈碱激动剂，在猫颈上神经节中研究了米安色林和阿米替林的抗毒蕈碱活性。结果发现，在该实验制剂中，米安色林的效价顺序与阿米替林相似，这与它们对非神经元毒蕈碱受体的抗毒蕈碱活性存在显著差异形成对比。这些发现表明，米安色林对神经元毒蕈碱受体的作用比基于非神经元受体研究预测的更为重要，且可能与其抗抑郁活性有关。
