McN-A-343对大脑皮层和心脏毒蕈碱受体的作用。
The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart.
作者信息
Birdsall N J, Burgen A S, Hulme E C, Stockton J M, Zigmond M J
出版信息
Br J Pharmacol. 1983 Feb;78(2):257-9. doi: 10.1111/j.1476-5381.1983.tb09388.x.
Abstract
McN-A-343 behaves as a competitive agonist in binding to muscarinic receptors in the cerebral cortex. In its interaction with myocardial muscarinic receptors it is not competitive but it retains features of agonist binding.
摘要
McN-A-343在与大脑皮层毒蕈碱受体结合时表现为竞争性激动剂。在与心肌毒蕈碱受体相互作用时，它不具有竞争性，但保留了激动剂结合的特征。
相似文献
1
The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart.McN-A-343对大脑皮层和心脏毒蕈碱受体的作用。
Br J Pharmacol. 1983 Feb;78(2):257-9. doi: 10.1111/j.1476-5381.1983.tb09388.x.
2
Muscarinic activity of McN-A-343 and its value in muscarinic receptor classification.McN-A-343的毒蕈碱活性及其在毒蕈碱受体分类中的价值。
Br J Pharmacol. 1987 Apr;90(4):693-700. doi: 10.1111/j.1476-5381.1987.tb11222.x.
3
Pharmacological analysis of the muscarinic receptors involved when McN-A 343 stimulates acid secretion in the mouse isolated stomach.对 McN - A 343 刺激小鼠离体胃分泌胃酸时所涉及的毒蕈碱受体进行药理学分析。
Br J Pharmacol. 1985 Nov;86(3):609-17. doi: 10.1111/j.1476-5381.1985.tb08937.x.
4
Pharmacological analysis of the mode of interaction of McN-A-343 at atrial muscarinic M2 receptors.McN-A-343 与心房毒蕈碱 M2 受体相互作用模式的药理学分析。
Eur J Pharmacol. 1997 Nov 27;339(2-3):153-6. doi: 10.1016/s0014-2999(97)01379-4.
5
Emesis induced by 4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium chloride (McN-A-343): evidence for a predominant central muscarinic M1 mediation.4-（间氯苯基氨甲酰氧基）-2-丁炔基三甲基氯化铵（McN-A-343）诱导的呕吐：主要由中枢毒蕈碱M1介导的证据
Neuropharmacology. 1988 Sep;27(9):949-56. doi: 10.1016/0028-3908(88)90123-2.
6
Effect of specific M1, M2 muscarinic receptor agonists on REM sleep generation.
Brain Res. 1989 Nov 27;503(1):128-31. doi: 10.1016/0006-8993(89)91712-5.
7
The interaction of McN-A-343 with pirenzepine and other selective muscarine receptor antagonists at a prejunctional muscarine receptor.McN-A-343与哌仑西平和其他选择性毒蕈碱受体拮抗剂在节前毒蕈碱受体上的相互作用。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Feb;328(4):430-8. doi: 10.1007/BF00692912.
8
Characterization of the muscarine receptor type on paracrine cells activated by McN-A-343 in the mouse isolated stomach.在小鼠离体胃中对由McN-A-343激活的旁分泌细胞上毒蕈碱受体类型的表征。
Naunyn Schmiedebergs Arch Pharmacol. 1990 Mar;341(3):165-70. doi: 10.1007/BF00169726.
9
Pharmacological characterization of muscarinic receptors involved in McN-A-343-induced effects on intestinal motility and heart rate in conscious dogs.毒蕈碱受体的药理学特性：其参与了 McN - A - 343 对清醒犬肠道蠕动和心率的影响
Br J Pharmacol. 1988 Jun;94(2):566-72. doi: 10.1111/j.1476-5381.1988.tb11562.x.
10
M2 muscarinic receptor agonists produce hypotension and bradycardia when injected into the nucleus tractus solitarii.M2毒蕈碱受体激动剂注入孤束核时会引起低血压和心动过缓。
Brain Res. 1989 Jan 16;477(1-2):358-62. doi: 10.1016/0006-8993(89)91427-3.
引用本文的文献
1
Drug Design Targeting the Muscarinic Receptors and the Implications in Central Nervous System Disorders.靶向毒蕈碱受体的药物设计及其对中枢神经系统疾病的影响
Biomedicines. 2022 Feb 7;10(2):398. doi: 10.3390/biomedicines10020398.
2
Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficits.M1 mAChR 变构和双位点配体的开发：治疗认知障碍的潜在治疗方法。
ACS Chem Neurosci. 2013 Jul 17;4(7):1026-48. doi: 10.1021/cn400086m. Epub 2013 May 23.
3
Investigating the interaction of McN-A-343 with the M muscarinic receptor using its nitrogen mustard derivative and ACh mustard.使用氮芥衍生物和乙酰胆碱芥子气研究 McN-A-343 与 M 型毒蕈碱受体的相互作用。
Br J Pharmacol. 2010 Jul;160(6):1534-49. doi: 10.1111/j.1476-5381.2010.00810.x.
4
Rational design of dualsteric GPCR ligands: quests and promise.双位构象 G 蛋白偶联受体配体的合理设计：探索与展望。
Br J Pharmacol. 2010 Mar;159(5):997-1008. doi: 10.1111/j.1476-5381.2009.00601.x. Epub 2010 Feb 5.
5
Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.M4 毒蕈碱型乙酰胆碱受体变构调节剂的作用机制及其体内验证，具有潜在的抗精神病特性。
Neuropsychopharmacology. 2010 Mar;35(4):855-69. doi: 10.1038/npp.2009.194. Epub 2009 Nov 25.
6
Investigating the interaction of McN-A-343 with the M2 muscarinic receptor using its nitrogen mustard derivative.研究其氮芥衍生物与 M2 毒蕈碱受体相互作用。
Biochem Pharmacol. 2010 Apr 1;79(7):1025-35. doi: 10.1016/j.bcp.2009.11.005. Epub 2009 Nov 12.
7
Allosteric modulation of muscarinic acetylcholine receptors.变构调节毒蕈碱型乙酰胆碱受体。
Curr Neuropharmacol. 2007 Sep;5(3):157-67. doi: 10.2174/157015907781695946.
8
A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.G蛋白偶联受体功能选择性的一种新机制。毒蕈碱部分激动剂McN-A-343作为一种双位点正构/别构配体。
J Biol Chem. 2008 Oct 24;283(43):29312-21. doi: 10.1074/jbc.M803801200. Epub 2008 Aug 22.
9
On the analysis of ligand-directed signaling at G protein-coupled receptors.关于G蛋白偶联受体配体导向信号传导的分析。
Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):549-77. doi: 10.1007/s00210-008-0260-4. Epub 2008 Feb 6.
10
Allosteric drugs acting at muscarinic acetylcholine receptors.作用于毒蕈碱型乙酰胆碱受体的变构药物。
Neurochem Res. 2003 Apr;28(3-4):419-22. doi: 10.1023/a:1022888332221.
本文引用的文献
1
An unusual type of sympathetic ganglionic stimulant.一种不寻常类型的交感神经节兴奋剂。
J Pharmacol Exp Ther. 1961 May;132:156-70.
2
Pirenzepine distinguishes between different subclasses of muscarinic receptors.哌仑西平可区分毒蕈碱受体的不同亚类。
Nature. 1980 Jan 3;283(5742):90-2. doi: 10.1038/283090a0.
3
The character of the muscarinic receptors in different regions of the rat brain.大鼠脑不同区域毒蕈碱受体的特性
Proc R Soc Lond B Biol Sci. 1980 Feb 13;207(1166):1-12. doi: 10.1098/rspb.1980.0011.
4
Effects of several muscarinic agonists on cardiac performance and the release of noradrenaline from sympathetic nerves of the perfused rabbit heart.几种毒蕈碱激动剂对灌注兔心脏的心脏功能及交感神经去甲肾上腺素释放的影响。
Br J Pharmacol. 1972 Aug;45(4):616-29. doi: 10.1111/j.1476-5381.1972.tb08119.x.
5
The binding of antagonists to brain muscarinic receptors.拮抗剂与脑内毒蕈碱受体的结合。
Mol Pharmacol. 1978 Sep;14(5):737-50.
6
The binding of agonists to brain muscarinic receptors.激动剂与脑毒蕈碱受体的结合。
Mol Pharmacol. 1978 Sep;14(5):723-36.
7
Agonist-antagonist interactions with rat atrial muscarinic cholinergic receptor sites: differential regulation by guanine nucleotides.激动剂-拮抗剂与大鼠心房毒蕈碱胆碱能受体位点的相互作用：鸟嘌呤核苷酸的差异调节
Eur J Pharmacol. 1979 Sep 1;58(1):91-2. doi: 10.1016/0014-2999(79)90346-7.
8
The regulation of muscarinic cholinergic receptors by guanine nucleotides in cardiac tissue.鸟嘌呤核苷酸对心脏组织中毒蕈碱型胆碱能受体的调节作用。
Eur J Pharmacol. 1979 Jun;56(1-2):179-80. doi: 10.1016/0014-2999(79)90451-5.
9
Guanine nucleotides modulate muscarinic receptor binding in the heart.鸟嘌呤核苷酸调节心脏中的毒蕈碱受体结合。
Biochem Biophys Res Commun. 1979 Apr 27;87(4):1000-5. doi: 10.1016/s0006-291x(79)80006-6.
Zotero 插件