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1
The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart.McN-A-343对大脑皮层和心脏毒蕈碱受体的作用。
Br J Pharmacol. 1983 Feb;78(2):257-9. doi: 10.1111/j.1476-5381.1983.tb09388.x.
2
Muscarinic activity of McN-A-343 and its value in muscarinic receptor classification.McN-A-343的毒蕈碱活性及其在毒蕈碱受体分类中的价值。
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3
Pharmacological analysis of the muscarinic receptors involved when McN-A 343 stimulates acid secretion in the mouse isolated stomach.对 McN - A 343 刺激小鼠离体胃分泌胃酸时所涉及的毒蕈碱受体进行药理学分析。
Br J Pharmacol. 1985 Nov;86(3):609-17. doi: 10.1111/j.1476-5381.1985.tb08937.x.
4
Pharmacological analysis of the mode of interaction of McN-A-343 at atrial muscarinic M2 receptors.McN-A-343 与心房毒蕈碱 M2 受体相互作用模式的药理学分析。
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Emesis induced by 4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium chloride (McN-A-343): evidence for a predominant central muscarinic M1 mediation.4-（间氯苯基氨甲酰氧基）-2-丁炔基三甲基氯化铵（McN-A-343）诱导的呕吐：主要由中枢毒蕈碱M1介导的证据
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8
Characterization of the muscarine receptor type on paracrine cells activated by McN-A-343 in the mouse isolated stomach.在小鼠离体胃中对由McN-A-343激活的旁分泌细胞上毒蕈碱受体类型的表征。
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Pharmacological characterization of muscarinic receptors involved in McN-A-343-induced effects on intestinal motility and heart rate in conscious dogs.毒蕈碱受体的药理学特性：其参与了 McN - A - 343 对清醒犬肠道蠕动和心率的影响
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M2 muscarinic receptor agonists produce hypotension and bradycardia when injected into the nucleus tractus solitarii.M2毒蕈碱受体激动剂注入孤束核时会引起低血压和心动过缓。
Brain Res. 1989 Jan 16;477(1-2):358-62. doi: 10.1016/0006-8993(89)91427-3.

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A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.G蛋白偶联受体功能选择性的一种新机制。毒蕈碱部分激动剂McN-A-343作为一种双位点正构/别构配体。
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An unusual type of sympathetic ganglionic stimulant.一种不寻常类型的交感神经节兴奋剂。
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2
Pirenzepine distinguishes between different subclasses of muscarinic receptors.哌仑西平可区分毒蕈碱受体的不同亚类。
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The character of the muscarinic receptors in different regions of the rat brain.大鼠脑不同区域毒蕈碱受体的特性
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Effects of several muscarinic agonists on cardiac performance and the release of noradrenaline from sympathetic nerves of the perfused rabbit heart.几种毒蕈碱激动剂对灌注兔心脏的心脏功能及交感神经去甲肾上腺素释放的影响。
Br J Pharmacol. 1972 Aug;45(4):616-29. doi: 10.1111/j.1476-5381.1972.tb08119.x.
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The binding of antagonists to brain muscarinic receptors.拮抗剂与脑内毒蕈碱受体的结合。
Mol Pharmacol. 1978 Sep;14(5):737-50.
6
The binding of agonists to brain muscarinic receptors.激动剂与脑毒蕈碱受体的结合。
Mol Pharmacol. 1978 Sep;14(5):723-36.
7
Agonist-antagonist interactions with rat atrial muscarinic cholinergic receptor sites: differential regulation by guanine nucleotides.激动剂-拮抗剂与大鼠心房毒蕈碱胆碱能受体位点的相互作用：鸟嘌呤核苷酸的差异调节
Eur J Pharmacol. 1979 Sep 1;58(1):91-2. doi: 10.1016/0014-2999(79)90346-7.
8
The regulation of muscarinic cholinergic receptors by guanine nucleotides in cardiac tissue.鸟嘌呤核苷酸对心脏组织中毒蕈碱型胆碱能受体的调节作用。
Eur J Pharmacol. 1979 Jun;56(1-2):179-80. doi: 10.1016/0014-2999(79)90451-5.
9
Guanine nucleotides modulate muscarinic receptor binding in the heart.鸟嘌呤核苷酸调节心脏中的毒蕈碱受体结合。
Biochem Biophys Res Commun. 1979 Apr 27;87(4):1000-5. doi: 10.1016/s0006-291x(79)80006-6.

McN-A-343对大脑皮层和心脏毒蕈碱受体的作用。

The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart.

作者信息

Birdsall N J, Burgen A S, Hulme E C, Stockton J M, Zigmond M J

出版信息

Br J Pharmacol. 1983 Feb;78(2):257-9. doi: 10.1111/j.1476-5381.1983.tb09388.x.

DOI:10.1111/j.1476-5381.1983.tb09388.x
PMID:6187403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044719/
Abstract

McN-A-343 behaves as a competitive agonist in binding to muscarinic receptors in the cerebral cortex. In its interaction with myocardial muscarinic receptors it is not competitive but it retains features of agonist binding.

摘要

McN-A-343在与大脑皮层毒蕈碱受体结合时表现为竞争性激动剂。在与心肌毒蕈碱受体相互作用时，它不具有竞争性，但保留了激动剂结合的特征。