Hasan S S, Mazumdar S, Singh P M, Pandey S N
Nuklearmedizin. 1981 Apr;20(2):82-4.
This study was undertaken to try a newly synthesized compound (1-acetyl hydrazinyl thiophenyl formamidine dihydrochlorie) as a chemical radioprotector and to observe its effects on adrenal catecholamine and protein bound iodine (PBI). After whole-body irradiation, the catecholamine and serum PBI levels decreased significantly but treatment with the drug before irradiation increased the same. The whole-body irradiation resulted in a 50% mortality within a fortnight whereas the use of the drug prevented it.
本研究旨在尝试一种新合成的化合物（1-乙酰肼基硫代苯基甲脒二盐酸盐）作为化学辐射防护剂，并观察其对肾上腺儿茶酚胺和蛋白结合碘（PBI）的影响。全身照射后，儿茶酚胺和血清PBI水平显著降低，但照射前使用该药物可使其升高。全身照射导致两周内死亡率达50%，而使用该药物可预防死亡。
