γ-内啡肽具有类抗精神病药物活性的进一步证据。
Further evidence for the neuroleptic-like activity of gamma-endorphin.
作者信息
Király I, Tapfer M, Borsy J, Gráf L
出版信息
Peptides. 1981 Spring;2(1):9-12. doi: 10.1016/s0196-9781(81)80004-6.
PMID:6165979
Abstract
gamma-Endorphin inhibits the amphetamine-induced stereotypy in rats with an approximate ED50 of 0.3 mg/kg. SC. The anti-amphetamine effect of gamma-endorphin can be antagonized to a certain extent by both the dopamine receptor stimulant 2-bromo-ergocryptine and the opiate receptor antagonist naloxone.
摘要
γ-内啡肽可抑制大鼠中苯丙胺诱导的刻板行为，皮下注射时的半数有效剂量（ED50）约为0.3mg/kg。γ-内啡肽的抗苯丙胺作用在一定程度上可被多巴胺受体激动剂2-溴麦角隐亭和阿片受体拮抗剂纳洛酮所拮抗。
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