体外从克隆的乳腺上皮细胞生成成纤维样细胞：一种可能的新细胞类型。
Generation of fibroblast-like cells from cloned epithelial mammary cells in vitro: a possible new cell type.
作者信息
Dulbecco R, Henahan M, Bowman M, Okada S, Battifora H, Unger M
出版信息
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2345-9. doi: 10.1073/pnas.78.4.2345.
We have isolated clonal cell lines from a nitrosomethylurea-induced mammary tumor in Wistar--Furth rats. The epithelial-like cells of these lines give rise to fibroblast-like cells. A study of several markers showed that the epithelial-like cells are similar to epithelial mammary cells. The fibroblastic cells, however, were similar to stromal cells, except for the production of collagen IV. The events occurring in these cultures are identical to those observed in previously isolated mammary cultures [Bennett, D. C., Peachey, L. A., Durbin, H. & Rudland, P. S. (1976) Cell 15, 283--298], suggesting their generality. The fibroblast-like cells generated in culture may be a hitherto unrecognized type of mammary cell.
我们从经亚硝基甲基脲诱导的Wistar-Furth大鼠乳腺肿瘤中分离出了克隆细胞系。这些细胞系的上皮样细胞可产生成纤维细胞样细胞。对多种标志物的研究表明，上皮样细胞与乳腺上皮细胞相似。然而，成纤维细胞除了能产生IV型胶原外，与基质细胞相似。这些培养物中发生的事件与先前分离的乳腺培养物中观察到的事件相同[贝内特，D.C.，皮奇，L.A.，德宾，H.和鲁德兰，P.S.（1976年）《细胞》15卷，283 - 298页]，表明这些事件具有普遍性。培养中产生的成纤维细胞样细胞可能是一种迄今未被认识的乳腺细胞类型。
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