一种由髓单核细胞系细胞表达的抗原。

An antigen expressed by cells of the myelo-monocytic lineage.

作者信息

Foon K A, Billing R J, Fitchen J H, Belzer M, Drew S I, Terasaki P I

出版信息

Am J Hematol. 1981;10(3):259-67. doi: 10.1002/ajh.2830100305.

Abstract

We describe an antigen(s) characterized by a heteroantiserum raised in rabbits against mature human granulocytes. This antigen was found on neutrophils, monocytes, platelets, acute and chronic myelocytic leukemia cells and on granulocyte-macrophage progenitor cells grown in agar. It was not found on lymphocytes, eosinophils, erythrocytes, or erythroid progenitor cells. On the basis of tissue distribution and absorption studies, the antigen (tentatively designated the "myelo-monocytic" antigen) is distinct from antigens previously identified on human neutrophils. Restriction of the "myelo-monocytic" antigen to normal and malignant cells of the myelo-monocytic series suggests that it may represent a normal differentiation antigen of the myelo-monocytic lineage.

摘要

我们描述了一种抗原，其特征是由兔抗成熟人粒细胞产生的异种抗血清所识别。该抗原存在于中性粒细胞、单核细胞、血小板、急慢性髓细胞白血病细胞以及琼脂培养的粒-巨噬细胞祖细胞上。在淋巴细胞、嗜酸性粒细胞、红细胞或红系祖细胞上未发现该抗原。基于组织分布和吸收研究，该抗原（暂定为“髓单核细胞”抗原）与先前在人中性粒细胞上鉴定出的抗原不同。“髓单核细胞”抗原在髓单核细胞系列的正常和恶性细胞中的局限性表明，它可能代表髓单核细胞谱系的一种正常分化抗原。