Konturek S J, Jaworek J, Tasler J, Cieszkowski M, Pawlik W
Am J Physiol. 1981 Jul;241(1):G74-81. doi: 10.1152/ajpgi.1981.241.1.G74.
In five dogs with gastric fistulas, Heidenhain pouches, and pancreatic fistulas, the effects of substance P (SP) and its C-terminal hexapeptide (SP6-11) on gastric acid and pancreatic secretions were determined under basal conditions and in response to secretory stimulation. SP or SP6-11 infused alone in graded doses (0.25-2.0 nmol.kg-1.h-1) caused a slight but significant increase in pancreatic secretions in fasted dogs, but, when given during the secretory stimulation, they caused significant inhibition of these secretions. They reduced gastric acid response to pentagastrin and peptone meal without affecting the serum gastrin level. They caused dose-dependent inhibition of secretin-induced pancreatic bicarbonate secretion and suppressed the pancreatic protein response to caerulein, feeding, and duodenal acidification. SP6-11 was equipotent on a molar basis with SP in the inhibition of gastric or pancreatic secretion, indicating that the C-terminal portion of SP exhibits a full spectrum of the biological action of the intact molecule. The inhibitory effects of SP and SP6-11 on the stomach and pancreas were observed at a dose range that was without any significant influence on the blood pressure, indicating that they are not caused by the interference of the blood flow to the pancreas.
在五只患有胃瘘、海登海因袋和胰瘘的狗身上，测定了P物质（SP）及其C末端六肽（SP6-11）在基础条件下以及对分泌刺激的反应中对胃酸和胰腺分泌的影响。单独以分级剂量（0.25 - 2.0 nmol·kg⁻¹·h⁻¹）输注SP或SP6-11，在禁食的狗中引起胰腺分泌轻微但显著增加，但在分泌刺激期间给予时，它们会导致这些分泌显著抑制。它们降低了对五肽胃泌素和蛋白胨餐的胃酸反应，而不影响血清胃泌素水平。它们引起对促胰液素诱导的胰腺碳酸氢盐分泌的剂量依赖性抑制，并抑制了对雨蛙素、进食和十二指肠酸化的胰腺蛋白反应。在抑制胃或胰腺分泌方面，SP6-11在摩尔基础上与SP等效，表明SP的C末端部分表现出完整分子的全谱生物活性。在对血压无任何显著影响的剂量范围内观察到SP和SP6-11对胃和胰腺的抑制作用，表明它们不是由对胰腺血流的干扰引起的。
