Silverberg I J, Phillips T L, Fu K K, Chan P Y
Cancer Treat Rep. 1981 Jul-Aug;65(7-8):697-8.
Forty-two patients with inoperable stage III or IV head and neck epithelial tumors were entered in a phase I pilot study to evaluate the toxicity and efficacy of combined radiotherapy and bleomycin for advanced head and neck cancers. Twenty-three patients (52%) achieved complete remissions and 18 patients (42%) had greater than 50% regression. Most patients tolerated bleomycin at a dose of 5 units twice a week, with a full course of radiotherapy delivered at 1809 rads/day, 5 days/week. Although the complete remission rate appears to be higher than with radiotherapy alone and 13 of the 23 complete remissions (57%) lasted greater than 1 year, methods of prolonging the duration of remission need to be developed.
42例无法手术的Ⅲ期或Ⅳ期头颈部上皮性肿瘤患者进入一项Ⅰ期初步研究，以评估联合放疗和博来霉素治疗晚期头颈部癌症的毒性和疗效。23例患者（52%）实现完全缓解，18例患者（42%）肿瘤消退超过50%。大多数患者能够耐受每周两次、每次5单位博来霉素的剂量，放疗全程剂量为每天1809拉德，每周5天。虽然完全缓解率似乎高于单纯放疗，且23例完全缓解患者中有13例（57%）缓解持续时间超过1年，但仍需要开发延长缓解持续时间的方法。
