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[大肠菌素A的生物合成:信使核糖核酸翻译过程中停顿的存在]

[Biosynthesis of colicin A : existence of pauses in the translation of messenger RNA].

作者信息

Varenne S, Cavard D, Lazdunski C

出版信息

C R Seances Acad Sci III. 1981 Mar 16;292(11):701-4.

PMID:6166409
Abstract

Evidence has been obtained for the existence of nascent polypeptide chains, that transiently accumulate as discrete size classes, due to discontinuities in the translation process of the colicin A mRNA. Existence of these discontinuities is independent of the hot cell of colicinogenic factor, and from the induction of synthesis by mitomycin C. The information that leads to the existence of discontinuities in the mRNA translation is contained in the plasmid Col A and, very likely, in the Col A gene itself.

摘要

已经获得证据表明存在新生多肽链,由于大肠杆菌素A信使核糖核酸(mRNA)翻译过程中的不连续性,这些新生多肽链会以离散的大小类别短暂积累。这些不连续性的存在与产大肠杆菌素因子的宿主细胞无关,也与丝裂霉素C诱导的合成无关。导致mRNA翻译中出现不连续性的信息包含在质粒Col A中,很可能也包含在Col A基因本身中。

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