Leitch A G, Lumb E M, Kay A B
Clin Allergy. 1981 May;11(3):257-62. doi: 10.1111/j.1365-2222.1981.tb01592.x.
We have measured the concentrations of mediators of hypersensitivity in the sputum of twenty-five young, symptomatic cigarette smokers who regularly expectorated and twenty-three matched non-smokers with a respiratory infection. The measurements included sputum and blood eosinophils, IgE, IgG, IgA and IgM and also sputum histamine. We found a significant increase of sputum histamine, and a higher sputum/serum ratio of IgE in smokers when compared to non-smokers. These findings support the view that the bronchial inflammatory response in smokers, as in chronic bronchitis, involves the participation of mediators of hypersensitivity.
我们测量了25名有症状的年轻经常咳痰的吸烟患者以及23名匹配的患有呼吸道感染的非吸烟患者痰液中过敏介质的浓度。测量项目包括痰液和血液中的嗜酸性粒细胞、IgE、IgG、IgA和IgM，还有痰液组胺。我们发现，与非吸烟者相比，吸烟者痰液组胺显著增加，且痰液/血清IgE比值更高。这些发现支持了这样一种观点，即吸烟者的支气管炎症反应，如同在慢性支气管炎中一样，涉及过敏介质的参与。
