Turnbull L W, Turnbull L S, Crofton J, Kay A B
Lancet. 1978 Jul 22;2(8082):184-6. doi: 10.1016/s0140-6736(78)91922-0.
Histamine, slow reacting substance of anaphylaxis (S.R.S.-A), IgE, eosinophils, and an eosinophil-associated enzyme, arylsulphatase IIB, were measured in sputum from 11 chronic bronchitics at weekly intervals for 6 weeks. The agents were detected in all patients at some time and in the majority at all times throughout the study period although their concentrations varied. The variations in histamine, S.R.S.-A and IgE gave a highly significant negative correlation with the peak expiratory flow-rate, suggesting that chemical mediators of hypersensitivity may play some role in the pathogenesis of airways obstruction in this disease. Sputum eosinophilia correlated with the arylsulphatase IIB concentration but not with the peak expiratory flow-rate, IgE, histamine, or S.R.S.-A, a finding consistent with the view that eosinophils accumulate at the site of type I reactions after the peak of mediator release.
对11例慢性支气管炎患者的痰液进行了为期6周的每周一次的检测，测定其中组胺、过敏反应慢反应物质（S.R.S.-A）、免疫球蛋白E（IgE）、嗜酸性粒细胞以及一种与嗜酸性粒细胞相关的酶——芳基硫酸酯酶IIB的含量。在整个研究期间，所有患者在某些时候都检测到了这些物质，大多数患者在整个期间都能检测到，尽管其浓度有所变化。组胺、S.R.S.-A和IgE的变化与呼气峰值流速呈高度显著的负相关，这表明超敏反应的化学介质可能在该疾病气道阻塞的发病机制中起一定作用。痰液嗜酸性粒细胞增多与芳基硫酸酯酶IIB浓度相关，但与呼气峰值流速、IgE、组胺或S.R.S.-A无关，这一发现与以下观点一致，即嗜酸性粒细胞在介质释放高峰后在I型反应部位聚集。
