Virus R M, Knuepfer M M, McManus D Q, Brody M J, Gebhart G F
Eur J Pharmacol. 1981 Jun 19;72(2-3):209-17. doi: 10.1016/0014-2999(81)90275-2.
Effects of s.c. capsaicin pretreatment on nociception, mean systemic arterial blood pressure, and dose-response curves for depressor effects of substance P (SP) and pressor effects of angiotension II (AII) and norepinephrine (NE) were examined in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Capsaicin pretreatment significantly elevated hot plate and tail flick latencies in SHR subjects but was without effect in WKY rats. Capsaicin pretreatment significantly reduced mean systemic arterial blood pressure in rats of both strains. Both vehicle- and capsaicin-treated WKY subjects exhibited greater depressor responses than did subjects of the corresponding SHR groups after i.v. SP administration. Vehicle-treated SHR subjects exhibited greater pressor responses to both AII and NE than did rats of the vehicle-treated WKY group. Capsaicin treatment decreased the sensitivity of WKY rats to the pressor effects of both AII and NE. Strain differences involving nociception, cardiovascular regulation, and responses to capsaicin may underly the results reported.
在正常血压的Wistar-Kyoto（WKY）大鼠和自发性高血压大鼠（SHR）中，研究了皮下注射辣椒素预处理对伤害感受、平均体循环动脉血压以及P物质（SP）降压作用、血管紧张素II（AII）和去甲肾上腺素（NE）升压作用的剂量-反应曲线的影响。辣椒素预处理显著提高了SHR组的热板和甩尾潜伏期，但对WKY大鼠没有影响。辣椒素预处理显著降低了两种品系大鼠的平均体循环动脉血压。静脉注射SP后，WKY组中经载体和辣椒素处理的大鼠比相应SHR组的大鼠表现出更大的降压反应。经载体处理的SHR大鼠对AII和NE的升压反应均比经载体处理的WKY组大鼠更强。辣椒素处理降低了WKY大鼠对AII和NE升压作用的敏感性。涉及伤害感受、心血管调节以及对辣椒素反应的品系差异可能是所报道结果的基础。
