Müllbacher A, Sheena J H, Fierz W, Brenan M
J Immunol. 1981 Aug;127(2):686-9.
Haplotype preference in the cytotoxic T cell response to H-Y in B10 congenic mice is only found in (B10 X B10.S)F1 hybrids. (B10 X B10.BR)F1 and (B10 X B10.D2)F1 do not generally show haplotype preference. H-2s is the preferred haplotype in H-Y immune (B10 X B10.S)F1 Tc cells. This haplotype preference is antigen specific since no preference was observed in the anti-influenza responses in (B10 X B10.S)F1 hybrids. Feedback inhibition as an explanation for haplotype preference could be excluded, but cross-reactivity of B10 H-Y immune Tc cells on B10.S targets suggests that natural tolerance may be responsible for haplotype preference.
在B10同源基因小鼠中，细胞毒性T细胞对H-Y的反应中的单倍型偏好仅在（B10×B10.S）F1杂种中发现。（B10×B10.BR）F1和（B10×B10.D2）F1通常不显示单倍型偏好。H-2s是H-Y免疫（B10×B10.S）F1 Tc细胞中的首选单倍型。这种单倍型偏好是抗原特异性的，因为在（B10×B10.S）F1杂种的抗流感反应中未观察到偏好。作为单倍型偏好解释的反馈抑制可以被排除，但B10 H-Y免疫Tc细胞对B10.S靶标的交叉反应表明，自然耐受性可能是单倍型偏好的原因。
